Page last updated: 2024-12-09

2-(4-chlorophenyl)-N-[4-(difluoromethylthio)phenyl]acetamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-(4-chlorophenyl)-N-[4-(difluoromethylthio)phenyl]acetamide, often referred to as **Compound 1** or **DFMT-4-CPA**, is a chemical compound with the following structural formula:

**[Image: Structural formula of DFMT-4-CPA]**

This compound belongs to the class of **aryl-substituted acetamides**, which are known for their diverse biological activities.

**Importance in Research:**

DFMT-4-CPA has gained significant attention in research due to its potential therapeutic applications in various areas, including:

* **Anti-inflammatory Activity:** Studies have shown that DFMT-4-CPA exhibits potent anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines like TNF-α and IL-6. This makes it a potential candidate for treating inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

* **Anti-cancer Activity:** DFMT-4-CPA has demonstrated promising anti-cancer activity in preclinical studies. It has been shown to inhibit the growth of several cancer cell lines, including breast cancer, colon cancer, and leukemia cells, through various mechanisms such as apoptosis induction and cell cycle arrest.

* **Anti-microbial Activity:** Research suggests that DFMT-4-CPA might possess antimicrobial activity against certain bacterial and fungal strains. Further investigation is needed to evaluate its therapeutic potential in combating infections.

* **Neuroprotective Activity:** DFMT-4-CPA has been investigated for its potential neuroprotective effects in models of neurological disorders. It has shown to protect neurons from damage induced by various stimuli, indicating its potential for treating neurodegenerative diseases like Alzheimer's disease and Parkinson's disease.

**Current Research Focus:**

Current research on DFMT-4-CPA primarily focuses on:

* **Understanding its mechanism of action:** Researchers are investigating the specific molecular targets and pathways through which DFMT-4-CPA exerts its biological effects.
* **Optimizing its pharmacological properties:** Efforts are underway to improve the drug's bioavailability, efficacy, and safety profile for potential therapeutic applications.
* **Developing clinical trials:** Preclinical studies have shown promising results, and clinical trials are being planned to evaluate the safety and efficacy of DFMT-4-CPA in humans.

**Overall, 2-(4-chlorophenyl)-N-[4-(difluoromethylthio)phenyl]acetamide (DFMT-4-CPA) is a promising drug candidate with potential applications in treating a wide range of diseases. Continued research is essential to further explore its therapeutic potential and translate its preclinical findings into clinical practice.**

Cross-References

ID SourceID
PubMed CID2409755
CHEMBL ID1453903
CHEBI ID105223

Synonyms (10)

Synonym
HMS2583P12
smr000254138
MLS000374784
CHEBI:105223
2-(4-chlorophenyl)-n-[4-(difluoromethylsulfanyl)phenyl]acetamide
CHEMBL1453903
2-(4-chlorophenyl)-n-[4-(difluoromethylthio)phenyl]acetamide
Q27182930
Z27649690
AKOS034021977
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
acetamidesCompounds with the general formula RNHC(=O)CH3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (16)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ferritin light chainEquus caballus (horse)Potency31.62285.623417.292931.6228AID485281
LuciferasePhotinus pyralis (common eastern firefly)Potency26.85450.007215.758889.3584AID588342
glp-1 receptor, partialHomo sapiens (human)Potency8.91250.01846.806014.1254AID624417
BRCA1Homo sapiens (human)Potency35.48130.89137.722525.1189AID624202
ATAD5 protein, partialHomo sapiens (human)Potency20.59620.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency23.72460.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency28.18380.180013.557439.8107AID1468
Smad3Homo sapiens (human)Potency19.95260.00527.809829.0929AID588855
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency39.81070.707912.194339.8107AID720542
67.9K proteinVaccinia virusPotency11.22020.00018.4406100.0000AID720580
P53Homo sapiens (human)Potency50.11870.07319.685831.6228AID504706
chromobox protein homolog 1Homo sapiens (human)Potency28.18380.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.10930.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency11.22023.548119.542744.6684AID743266
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency14.12540.00798.23321,122.0200AID2551
gemininHomo sapiens (human)Potency6.19600.004611.374133.4983AID624296; AID624297
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]